The OSCE activities related to the disposal of liquid rocket fuel components focus primarily on chemical waste disposal and disposal of rocket fuel components (Mélange and Samin). The extensive period of storage of liquid rocket fuel components leads to their destabilization and active decomposition, posing major environmental and public health risks. Their spillages cause the creation of acute or deadly poisoning zones, affecting residential areas, surface and underground waters, railroads and motorways. These risks require a response that anticipates establishing of implementation framework and organization and close monitoring of active disposal and removal activities.